Living donor bone banking: processing and discarding--from procurement to therapeutic use

Area of Science:

• Biomedical Engineering
• Tissue Banking
• Transplantation

Background:

• Skeletal muscle and osteoarticular tissue banks are crucial for procuring, processing, storing, and distributing human tissues.
• Established protocols ensure tissue quality and recipient safety.

Purpose of the Study:

• To analyze the causes of bone tissue discard at Biotar Tissue Bank between January 2005 and December 2012.
• To identify trends in tissue discard rates and their contributing factors.

Main Methods:

• Retrospective analysis of bone tissue donations received by Biotar Tissue Bank.
• Categorization of discarded bone tissue based on rejection reasons.
• Statistical comparison of discard rates over the study period.

Main Results:

• Out of 3413 donated bones, 22.44% were discarded. Reactive serology (62.14%) and inappropriate blood sample collection/storage (30.81%) were the main discard causes.
• Discard rates due to improper blood sample handling decreased progressively.
• No significant changes in serology-related discard rates were observed.

Conclusions:

• Stringent donor screening and adherence to quality control protocols are essential for tissue banking success.
• Continuous commitment to safety is paramount for recipient well-being.
• Optimizing collection and storage procedures can reduce allograft discards.