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Updated: Apr 15, 2026
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
A Review of the Key Clinical Trials of 2014
Peter McKavanagh1, Claire McCune, Ian B Menown
1Craigavon Cardiac Centre, Southern Trust, Craigavon, BT63 5QQ, Northern Ireland, UK, mckavanagh@doctors.org.uk.
Insights
This review covers significant 2014 cardiology trials, including new heart failure (HF) treatments, acute coronary syndrome data, and advancements in interventional cardiology and electrophysiology, offering practical insights for clinicians.
Area of Science:
- Cardiovascular Medicine
- Clinical Trials
- Cardiology Research
Background:
- Multiple practice-changing cardiology trials were presented in 2014 at major international conferences.
- These studies spanned various subspecialties including heart failure, acute coronary syndromes, and electrophysiology.
Purpose of the Study:
- To review and contextualize key clinical trial results from 2014.
- To identify studies with potential to alter current cardiology practice or guide future research.
Main Methods:
- Systematic review of clinical trial results presented at major cardiology conferences in 2014.
- Searches included terms for heart failure, acute coronary syndrome, interventional cardiology, atrial fibrillation, electrophysiology, and coronary prevention.
- Selection criteria focused on trials with broad relevance and potential practice-changing impact.
Main Results:
- New data on heart failure treatments, including neprilysin inhibitors and intravenous ferric carboxymaltose.
- Updates on acute coronary syndromes, stable coronary artery disease, and percutaneous coronary interventions.
- Findings on transcatheter aortic valve intervention, atrial fibrillation management, electrophysiology devices, and coronary prevention strategies.
Conclusions:
- The paper provides a summary of significant 2014 clinical trials.
- The findings are of practical interest to both clinicians and researchers in cardiology.
Introduction:
Over the last year, multiple, potentially practice-changing, cardiology trials or studies have been published or presented at international meetings including the American College of Cardiology, European Association for Percutaneous Cardiovascular Interventions, European Society of Cardiology, Transcatheter Cardiovascular Therapeutics, Heart Failure Congress, Heart Rhythm Society, Heart Failure Society of America, American Society of Hypertension and the American Heart Association.
Methods:
Clinical trial results presented at major cardiology conferences during 2014 were reviewed by the authors. Search terms included heart failure (HF), acute coronary syndrome, stable coronary disease, interventional cardiology, atrial fibrillation, electrophysiology and coronary prevention. Selection criteria were trials of broad relevance to the cardiology community, those with potential to change current practice and those with potential to guide further phase III research.
Results:
In this paper, the authors describe and place in clinical context, new HF, data including neprilysin inhibitors, intravenous ferric carboxymaltose, potassium-absorbing compounds, quadripolar leads for cardiac resynchronization therapy and intraventricular device intervention. New trial data are also described for acute coronary syndromes (clopidogrel, prasugrel, ticagrelor), stable coronary artery disease (ivabradine), percutaneous coronary intervention (the role of thrombectomy or treatment of non-culprit lesions during primary intervention, pressure wire studies and outcomes of new stent designs), transcatheter aortic valve intervention data, atrial fibrillation (anticoagulation and direct current cardioversion), electrophysiology (leadless pacemaker devices, use of quinidine in Brugada syndrome) and coronary prevention (landmark Ezetimibe outcome data, PCSK9 clinical trials, childhood prevalence of hypertension, renal denervation for resistant hypertension and the role of cardiac computerized tomography in cardiovascular screening).
Conclusion:
This paper summarizes key clinical trials during 2014 and should be of practical interest to clinicians and cardiology researchers.
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