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Related Experiment Videos

Genetic amniocentesis: a twelve years' experience.

J V Dacus, R S Wilroy, R L Summitt

    American Journal of Medical Genetics
    |March 1, 1985
    PubMed
    Summary

    Genetic amniocentesis is a safe and accurate prenatal diagnostic procedure. It effectively identifies fetal abnormalities, with a low error rate, aiding in the detection of genetic defects.

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    Area of Science:

    • Medical Genetics
    • Prenatal Diagnosis
    • Obstetrics

    Background:

    • Genetic amniocentesis is a key prenatal diagnostic tool.
    • Evaluating its safety, accuracy, and incidence of abnormal findings is crucial.

    Purpose of the Study:

    • To analyze the incidence of abnormal findings in fetuses.
    • To assess the safety and accuracy of genetic amniocentesis.
    • To evaluate the impact of concurrent ultrasonography.

    Main Methods:

    • Analysis of 2,013 fetuses from 2,000 patients undergoing genetic amniocentesis.
    • Review of pregnancy outcomes, including spontaneous abortion and termination.
    • Calculation of error rates and tissue culture success rates.
    • Comparison of outcomes with and without concurrent ultrasonography.

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    Main Results:

    • 1% of fetuses were aneuploid, 1% had elevated alpha-fetoprotein.
    • Advanced maternal age was a primary indication for amniocentesis.
    • The procedure had a 0.15% error rate and 97.7% tissue culture success.
    • Concurrent ultrasonography reduced blood-tinged specimens from 15.0% to 5.2%.

    Conclusions:

    • Midtrimester amniocentesis is a safe and accurate procedure for prenatal diagnosis.
    • It is valuable for identifying fetal abnormalities and genetically determined defects.
    • Ultrasonography enhances specimen quality during the procedure.