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Value of pentraxin-3 and galectin-3 in acute coronary syndrome: a short-term prospective cohort study

Melvin George1, Elangovan Shanmugam2, Varsha Srivatsan2

  • 1Department of Cardiology, SRM Medical College Hospital & Research Centre, Kattankulathur, Kancheepuram, Chennai, Tamil Nadu 603203, India melvingeorge2003@gmail.com.

Therapeutic Advances in Cardiovascular Disease
|March 28, 2015
PubMed

Insights

High levels of pentraxin-3 and galectin-3 indicate worse outcomes in acute coronary syndrome (ACS). These biomarkers are associated with increased mortality and reduced heart function in ACS patients.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Acute Coronary Syndromes

Background:

  • Acute coronary syndrome (ACS) is a major global health concern.
  • Galectin-3 and pentraxin-3 are known prognostic biomarkers in heart failure.
  • Limited data exist on these biomarkers within the ACS population.

Purpose of the Study:

  • To identify variables affected by high pentraxin-3 and galectin-3 concentrations.
  • To assess the impact of these biomarkers on all-cause mortality in ACS patients.

Main Methods:

  • 160 patients were analyzed: STEMI (n=64), NSTEMI/UA (n=38), and controls (n=58).
  • Plasma pentraxin-3 and galectin-3 levels were measured at admission.
  • Major adverse cardiovascular events were tracked for 6 months.

Main Results:

  • Pentraxin-3 and galectin-3 levels were significantly higher in STEMI patients.
  • Higher biomarker levels correlated with increased mortality and lower left ventricular ejection fraction (LVEF).
  • Elevated galectin-3 was associated with lower estimated glomerular filtration rate (eGFR).

Conclusions:

  • Pentraxin-3 and galectin-3 show significant promise as prognostic biomarkers in ACS.
  • These biomarkers may help predict adverse outcomes in patients with acute coronary syndromes.
Abstract

Keywords:
acute coronary syndromeall-cause mortalityestimated glomerular filtration rategalectin-3left ventricular ejection fractionpentraxin-3

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