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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Acne Infection01:27

Acne Infection

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

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Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Related Experiment Video

Updated: Apr 15, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Thalidomide in dermatology: revisited.

Iffat Hassan1, Konchok Dorjay1, Parvaiz Anwar1

  • 1Department of Dermatology, STD and Leprosy, Government Medical College, Srinagar, Jammu and Kashmir, India.

Indian Journal of Dermatology
|March 28, 2015
PubMed
Summary

Thalidomide is a useful dermatological drug for various skin conditions, but it carries significant risks, including birth defects like phocomelia. This review comprehensively covers thalidomide

Area of Science:

  • Dermatology
  • Pharmacology
  • Teratology

Background:

  • Thalidomide has a well-established history in dermatological treatment.
  • Extensive literature exists on thalidomide's multifaceted applications and properties.
  • Despite its efficacy, thalidomide is associated with severe health hazards, notably teratogenicity.

Purpose of the Study:

  • To provide a comprehensive review of thalidomide.
  • To detail the applications of thalidomide in dermatology.
  • To discuss the associated risks and benefits of thalidomide therapy.

Main Methods:

  • Literature review of existing studies on thalidomide.
  • Synthesis of data regarding dermatological uses.
  • Analysis of safety profiles and adverse events, including birth defects.
Keywords:
Dermatosesphocomeliathalidomide

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Main Results:

  • Thalidomide is effective for several dermatoses.
  • Significant teratogenic risks, such as phocomelia, are associated with thalidomide.
  • A balance between therapeutic benefits and severe risks must be considered.

Conclusions:

  • Thalidomide remains a valuable therapeutic option in dermatology.
  • Strict monitoring and risk management are essential due to its teratogenicity.
  • Further research may explore safer alternatives or optimized usage protocols.