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Metabolic reprograming of mononuclear phagocytes in progressive multiple sclerosis
Gillian Margaret Tannahill1, Nunzio Iraci1, Edoardo Gaude2
1Department of Clinical Neurosciences, NIHR Biomedical Research Centre, University of Cambridge , Cambridge , UK ; Wellcome Trust-Medical Research Council (MRC) Stem Cell Institute , Cambridge , UK.
Frontiers in Immunology
|March 28, 2015
Summary
Reprogramming mononuclear phagocyte (MP) metabolism may treat multiple sclerosis (MS). Targeting MP metabolic changes could offer new therapeutic strategies for this central nervous system (CNS) disease.
Area of Science:
- Neuroimmunology
- Cellular Metabolism
Background:
- Multiple sclerosis (MS) is a CNS inflammatory and demyelinating disease.
- Mononuclear phagocytes (MPs) contribute to myelin damage in progressive MS.
- Current MS treatments have limitations in reversing neurological deficits and can cause adverse effects.
Purpose of the Study:
- To review metabolic changes in macrophage polarization.
- To explore the potential of MP metabolic reprogramming for MS treatment.
Main Methods:
- Review of current literature on macrophage polarization and metabolism.
- Analysis of metabolic shifts in M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophages.
- Discussion of therapeutic implications of metabolic interventions.
Main Results:
- Macrophage polarization is linked to distinct metabolic pathways (M1: glycolysis, M2: oxidative metabolism).
- Metabolic reprogramming influences MP function and immune cell activation.
- Targeting MP metabolism presents a potential therapeutic avenue.
Conclusions:
- MPs are key mediators of inflammation in progressive MS.
- Cellular metabolism critically regulates MP function.
- Metabolic reprogramming of MPs offers a promising strategy for promoting healing in MS.
