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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist

Rieko Takano1, Masao Yoshida1, Masahiro Inoue1

  • 1R&D Division, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

ACS Medicinal Chemistry Letters
|March 28, 2015
PubMed

Keywords:
GPR40agonistdiabetesglucose loweringinsulin secretagogue

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