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Updated: Apr 15, 2026

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice
Published on: July 23, 2017
Bioengineered stem cells as an alternative for islet cell transplantation
Sarah J Moore1, Boris L Gala-Lopez1, Andrew R Pepper1
1Sarah J Moore, Boris L Gala-Lopez, Andrew R Pepper, Rena L Pawlick, AM James Shapiro, Alberta Diabetes Institute, University of Alberta, Edmonton AB T6G 2E1, Canada.
Type 1 diabetes treatment shows promise with islet transplantation, but challenges remain. Stem cell and regenerative medicine offer potential future cures for this autoimmune condition.
Area of Science:
- Immunology
- Endocrinology
- Regenerative Medicine
Background:
- Type 1 diabetes results from autoimmune destruction of pancreatic beta cells.
- Current management relies on insulin therapy.
- Islet transplantation demonstrates the potential for cellular replacement therapy.
Purpose of the Study:
- To review current progress in clinical islet transplantation.
- To explore stem cell and regenerative medicine for future diabetes treatment.
Main Methods:
- Review of clinical islet transplantation data.
- Analysis of advancements in stem cell and regenerative medicine.
Main Results:
- Islet transplantation is a viable treatment but faces challenges.
- Stem cells (embryonic, adult pluripotential) and xenografts show potential but require further development.
Conclusions:
- Clinical islet transplantation offers a pathway to treating type 1 diabetes.
- Stem cell and regenerative medicine approaches hold significant promise for curative diabetes treatments.
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