Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retrograde tracing along "cystic duct" method to prevent biliary misidentification injury in laparoscopic cholecystectomy.

Updates in surgery·2020
Same author

Effects of Hydrogen Bonds between Polymeric Hole-Transporting Material and Organic Cation Spacer on Morphology of Quasi-Two-Dimensional Perovskite Grains and Their Performance in Light-Emitting Diodes.

ACS applied materials & interfaces·2020
Same author

Recyclable Non-Enzymatic Glucose Sensor Based on Ni/NiTiO<sub>3</sub> /TiO<sub>2</sub> Nanotube Arrays.

ChemPlusChem·2020
Same author

A ratiometric fluorescent probe for determination of the anthrax biomarker 2,6-pyridinedicarboxylic acid based on a terbium(III)- functionalized UIO-67 metal-organic framework.

Mikrochimica acta·2020
Same author

MicroRNA-432 Suppresses Invasion and Migration via E2F3 in Nasopharyngeal Carcinoma.

OncoTargets and therapy·2020
Same author

Stereoselective metabolism and potential adverse effects of chiral fungicide triadimenol on Eremias argus.

Environmental science and pollution research international·2020

Related Experiment Video

Updated: Jan 13, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
09:44

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Published on: October 15, 2019

12.9K

Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications.

Xuejun Zhu1, Wenjun Zhang2

  • 1Department of Chemical and Biomolecular Engineering, University of California, Berkeley Berkeley, CA, USA ; Energy Biosciences Institute, University of California, Berkeley Berkeley, CA, USA.

Frontiers in Chemistry
|March 28, 2015
PubMed
Summary
This summary is machine-generated.

Bioorthogonal chemistry enables tagging natural products like polyketides (PKs) and non-ribosomal peptides (NRPs) with chemical handles. This facilitates studying their action and developing improved drug derivatives.

Keywords:
alkyne-azide cycloadditionbioorthogonal chemistrybiosynthesisnatural product labelingnon-ribosomal peptidespolyketides

More Related Videos

Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes
10:43

Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes

Published on: October 3, 2019

6.4K
Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
14:02

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

9.0K

Related Experiment Videos

Last Updated: Jan 13, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
09:44

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Published on: October 15, 2019

12.9K
Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes
10:43

Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes

Published on: October 3, 2019

6.4K
Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
14:02

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

9.0K

Area of Science:

  • Bioorthogonal chemistry
  • Chemical biology
  • Drug discovery

Background:

  • Bioorthogonal chemistry is a powerful tool in drug discovery and chemical biology.
  • Its application has significantly advanced natural product research.

Purpose of the Study:

  • To survey strategies for installing chemical handles into natural product scaffolds.
  • To explore the use of bioorthogonal reactions for studying natural products and synthesizing derivatives.

Main Methods:

  • Installation of chemical handles into polyketides (PKs), non-ribosomal peptides (NRPs), and their hybrids.
  • Subsequent bioorthogonal reactions for visualization and synthesis.

Main Results:

  • Tagging enables visualization and study of natural product mechanisms of action.
  • Synthesized derivatives exhibit enhanced pharmaceutical properties.

Conclusions:

  • Discusses generalizable synthesis of tagged PKs/NRPs.
  • Considers the broader impact of natural product labeling on research.