Related Experiment Video
Updated: Apr 15, 2026

Chronic Constriction Injury of the Rat's Infraorbital Nerve IoN-CCI to Study Trigeminal Neuropathic Pain
Published on: September 21, 2015
The role of cingulate cortex in vicarious pain.
Esther H Yesudas1, Tatia M C Lee2
1Laboratory of Neuropsychology, The University of Hong Kong, Room 656, The Jockey Club Tower, Pokfulam Road, Hong Kong ; Laboratory of Social Cognitive Affective Neuroscience, The University of Hong Kong, Room 656, The Jockey Club Tower, Pokfulam Road, Hong Kong.
Observing pain activates brain regions like the cingulate cortex, similar to experiencing pain oneself. This vicarious pain processing is key for empathy, but specific neural roles require more research.
Area of Science:
- Neuroscience
- Psychology
- Cognitive Science
Background:
- Vicarious pain, the experience of pain from observing others, is linked to the cingulate cortex.
- Existing research highlights the cingulate cortex's role in self-experienced pain.
- Limited studies have investigated the cingulate cortex's specific functions in vicarious pain.
Purpose of the Study:
- To review neuroimaging studies on cingulate cortex activity during pain observation.
- To explore the neural overlap and distinctions between self-experienced and vicarious pain processing.
- To examine the differential roles of the cingulate cortex in empathy-related cognitive, affective, and motor functions.
Main Methods:
- Systematic review of one EEG and eighteen neuroimaging studies.
- Analysis of cingulate cortex activation patterns during pain observation.
- Synthesis of findings related to empathy induction and neural processing.
Main Results:
- Significant overlap in cingulate cortex activity between self-experienced and vicarious pain.
- Evidence suggests shared neural representations facilitating empathy and affective state inference.
- Differential functions of the cingulate cortex in cognitive, affective, and motor aspects of empathy require further investigation.
Conclusions:
- The cingulate cortex is crucial for vicarious pain and empathy, showing overlapping activity with self-pain processing.
- Understanding these neural correlates can identify biomarkers for empathic deficits in clinical disorders.
- Further research is needed to precisely map cingulate cortex functions in vicarious pain and empathy.
Related Concept Videos
Nociception
Pain
Somatosensory, Motor, and Association Cortex
Somatosensation
Analgesia and Pain Management
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...

