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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

Updated: Apr 15, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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[Cutaneous melanoma: about 200 cases].

Tarak Damak, Jamel Ben Hassouna, Achraf Hadiji

    La Tunisie Medicale
    |March 28, 2015
    PubMed
    Summary
    This summary is machine-generated.

    This study analyzed 200 cutaneous melanoma cases, identifying tumor size, location, and Clark level as key prognostic factors. Early diagnosis and prevention are crucial for improving patient survival rates in cutaneous melanoma.

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    Related Experiment Videos

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    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Context:

    • Cutaneous melanoma presents significant challenges due to its variable clinical and pathological features.
    • Understanding prognostic factors is essential for effective patient management and treatment strategies.

    Purpose:

    • To analyze clinical and pathological aspects of cutaneous melanoma.
    • To identify significant prognostic factors influencing patient outcomes.

    Summary:

    • A retrospective analysis of 200 cutaneous melanoma cases (1969-2005) revealed key prognostic indicators including tumor size (>2 cm), location (hands/feet), Clark level (IV/V), and margin involvement.
    • Metastasis-free survival was influenced by tumor size, location, resection type, and lymph node dissection.
    • Nodular melanoma and Grade V Clark level were prevalent, with a 5-year overall survival of 28.5%.

    Impact:

    • Findings highlight the importance of early diagnosis and preventive measures, such as photoprotection and surveillance for high-risk individuals.
    • Identified prognostic factors can guide clinical decision-making and risk stratification for cutaneous melanoma patients.
    • Improved understanding of melanoma progression and survival predictors can lead to more targeted therapeutic interventions.