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Updated: Sep 13, 2026

Quantitative Measurement of Relative Retinoic Acid Levels in E8.5 Embryos and Neurosphere Cultures Using the F9 RARE-Lacz Cell-based Reporter Assay
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Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review)

Shujiong Feng1, Song Xu1, Zhenzhen Wen1

  • 1Laboratory of Gastroenterology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.

International Journal of Molecular Medicine
|March 28, 2015
PubMed

Insights

Retinoic acid-related orphan receptor (ROR)β regulates bone formation and circadian rhythm. Aberrant RORβ-driven circadian disruption may promote cancer, offering new avenues for cancer prevention strategies.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cancer Research

Background:

  • Nuclear receptors are crucial transcription factors regulating diverse physiological processes.
  • Retinoic acid-related orphan receptor (ROR)β, an orphan nuclear receptor, impacts bone formation and circadian rhythm.
  • Disruptions in circadian rhythm are increasingly linked to tumorigenesis and cancer progression.

Purpose of the Study:

  • To review the role of RORβ in physiological and pathological processes.
  • To explore the connection between RORβ, circadian rhythm, and cancer.
  • To highlight RORβ as a potential target for cancer prevention.

Main Methods:

  • Literature review of studies on nuclear receptors, RORβ, circadian rhythm, and cancer.
  • Analysis of mechanisms linking aberrant RORβ activity to circadian disruption and tumorigenesis.

Main Results:

  • RORβ functions as an osteogenic repressor in bone formation.
  • RORβ is implicated in the regulation of circadian rhythm.
  • Aberrant RORβ activity can lead to circadian rhythm disruption, potentially promoting cancer.

Conclusions:

  • RORβ plays a significant role in bone homeostasis and circadian regulation.
  • Aberrant RORβ-mediated circadian disruption is a potential driver of tumorigenesis.
  • Targeting RORβ-induced circadian pathways may offer novel strategies for cancer prevention and treatment.

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