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Barnidipine real-life tolerability in arterial hypertension: results from the BASIC-HT study
Insights
Barnidipine, a calcium channel blocker, demonstrated good tolerability and adherence in hypertensive patients. This led to significant blood pressure reduction in a real-world setting.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Essential hypertension management is often hindered by poor patient adherence to medication.
- Effective treatments require a balance of efficacy and tolerability.
- Barnidipine, a lipophilic calcium channel blocker, offers comparable efficacy to other dihydropyridines.
Purpose of the Study:
- To evaluate the real-world tolerability of barnidipine in a large essential hypertension patient cohort.
- To assess the efficacy of barnidipine in a clinical practice setting.
Main Methods:
- An observational study involving 20,479 patients with essential hypertension.
- Tolerability and efficacy were assessed over a 3-month period across two visits.
- Analysis included 20,275 patients.
Main Results:
- Adverse events occurred in 10.6% of patients, with 3% discontinuing treatment due to adverse events.
- Expected adverse events associated with calcium channel blockers were observed.
- The overall dropout rate was 8%.
- Mean systolic blood pressure decreased from 159.6 to 138.2 mmHg, and diastolic blood pressure decreased from 92.5 to 81.7 mmHg.
Conclusions:
- Barnidipine treatment resulted in a significant reduction in blood pressure.
- Improved patient adherence to barnidipine therapy is likely responsible for the observed blood pressure decrease.
Introduction:
Blood pressure (BP) is generally poorly controlled in hypertensive patients. One cause is poor adherence to drugs, which can be improved by treatments combining good efficacy and tolerability. Barnidipine is a strong lipophilic calcium channel blocker (CCB) with efficacy similar to other dihydropyridines.
Objective:
BASIC HT is an observational study in a large population of patients with essential hypertension to evaluate the tolerability of barnidipine in a real-life setting.
Methods:
20479 patients were enrolled in the study. Tolerability and efficacy was assessed at 2 visits during a 3-month period. 20275 patients were included in the analysis.
Results:
Adverse events were reported by 10.6% of the patients, leading to treatment discontinuation in 3%. Events were those expected with CCBs. The drop-out rate was 8%. Mean systolic and diastolic pressure decreased from 159.6 to 138.2 and from 92.5 to 81.7 mmHg.
Conclusion:
The decrease in BP, is probably due to stimulation of good adherence by barnidipine.
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