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Updated: Apr 15, 2026

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies
Published on: January 31, 2013
A novel three-filament model of force generation in eccentric contraction of skeletal muscles
Gudrun Schappacher-Tilp1, Timothy Leonard2, Gertrud Desch1
1Department of Mathematics and Scientific Computing, University of Graz, 8010 Graz, Austria.
Abstract:
We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.
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