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Updated: Apr 15, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
The possible role of glutathione-S-transferase activity in diabetic nephropathy
M Tesauro1, S Nisticò2, A Noce1
1Department of Systems Medicine, Division of Hypertension and Nephrology, University of Rome "Tor Vergata", Rome, Italy.
Abstract:
The most common cause of end stage renal disease is diabetic nephropathy. An early diagnosis may allow an intervention to slow down disease progression. Recently, it has been hypothesized that glutathione-S-transferase (GST) activity may be a marker of severity of chronic kidney disease. In particular, a lower GST activity is present in healthy subjects compared to patients with nephropathy. In the present review we illustrate the scientific evidence underlying the possible role of GST activity in the development of diabetic nephropathy and we analyze its usefulness as a possible early biomarker of this diabetic complication.
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