Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

926
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
926
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

803
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
803
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

2.7K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
2.7K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.7K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.7K
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

802
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
802

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterisation of tumor-infiltrating gamma-delta T cells in human colorectal cancer with MHC-I loss.

Clinical & translational immunology·2026
Same author

Hypocomplementaemic urticarial vasculitis with mesangioproliferative glomerulonephritis, interstitial nephritis and absent immune staining.

Internal medicine journal·2026
Same author

Sensory neuropeptide CGRP and its co-receptor RAMP1 drive tumour cell growth in gastrointestinal cancers.

BMJ oncology·2025
Same author

Differentiation grade is highly concordant between matched primary and metastatic colorectal cancer.

Clinical & experimental metastasis·2025
Same author

The photoreceptor outer segment: Development and renewal.

Current topics in developmental biology·2025
Same author

Model systems and unique biological features of high and low-grade colorectal cancer (CRC) revealed by xenografting 84 human CRC cell lines.

Communications biology·2025

Related Experiment Video

Updated: Apr 15, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

24.6K

CADASIL syndrome.

David S Williams

    Journal of Insurance Medicine (New York, N.Y.)
    |March 31, 2015
    PubMed
    Summary
    This summary is machine-generated.

    This rare hereditary disorder causes migraine headaches, transient ischemic attacks, strokes, cognitive decline, and dementia. Early diagnosis and management are crucial for patients with this neurological condition.

    More Related Videos

    Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
    04:44

    Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

    Published on: June 16, 2020

    21.2K
    Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
    07:26

    Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

    Published on: January 31, 2025

    1.2K

    Related Experiment Videos

    Last Updated: Apr 15, 2026

    A Novel Method: Super-selective Adrenal Venous Sampling
    06:08

    A Novel Method: Super-selective Adrenal Venous Sampling

    Published on: September 15, 2017

    24.6K
    Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
    04:44

    Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

    Published on: June 16, 2020

    21.2K
    Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
    07:26

    Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

    Published on: January 31, 2025

    1.2K

    Area of Science:

    • Neurology
    • Genetics
    • Vascular Medicine

    Background:

    • A rare hereditary disorder presents with a complex array of neurological symptoms.
    • Characterized by recurrent migraine headaches, transient ischemic attacks (TIAs), and cerebrovascular events such as strokes.

    Purpose of the Study:

    • To describe the clinical manifestations and potential genetic underpinnings of this rare hereditary neurological disorder.
    • To highlight the progressive nature of cognitive decline and dementia associated with the condition.

    Main Methods:

    • Literature review of documented cases.
    • Analysis of clinical presentations including headache patterns, neurological deficits, and cognitive assessments.
    • Review of genetic studies investigating hereditary factors.

    Main Results:

    • Consistent association of migraine headaches with TIAs and strokes in affected individuals.
    • Progressive cognitive decline and dementia observed as a hallmark of the disorder.
    • Identification of potential hereditary patterns suggesting a genetic etiology.

    Conclusions:

    • This rare hereditary disorder necessitates a multidisciplinary approach for diagnosis and management.
    • Understanding the genetic basis is key to developing targeted therapies for stroke prevention and cognitive support.
    • Further research is warranted to elucidate the specific genetic mutations and molecular pathways involved.