Related Experiment Video
Updated: Apr 15, 2026

Murine Nasal Lavage Fluid Collection without Blood Contamination
Published on: July 11, 2025
Age changes of human serum polyreactive immunoglobulins (PRIG) activity
Serum polyreactive immunoglobulins (PRIG) activity changes with age. IgG PRIG activity significantly increases, while IgM PRIG activity remains stable or decreases in healthy adults.
Area of Science:
- Immunology
- Gerontology
- Biochemistry
Background:
- Serum polyreactive immunoglobulins (PRIG) play a role in immune responses.
- Understanding age-related changes in PRIG activity is crucial for assessing immune function in aging populations.
Purpose of the Study:
- To investigate the age-dependent variations in the activity of serum polyreactive immunoglobulins (PRIG) across different immunoglobulin classes (IgG, IgM, IgA).
Main Methods:
- Analysis of serum samples from healthy individuals aged 25 to 70.
- Quantification of PRIG activity for IgG, IgM, and IgA subclasses.
Main Results:
- Serum IgG PRIG activity demonstrated a significant age-related increase (3-4 fold).
- Serum IgM PRIG activity showed no consistent increase and sometimes decreased with age.
- Serum IgA PRIG activity exhibited greater variability and less age dependency compared to IgG PRIG.
Conclusions:
- Age significantly influences the activity of different PRIG subclasses in healthy adults.
- The distinct age-related patterns of IgG, IgM, and IgA PRIG suggest specific functional roles that warrant further investigation.
More Related Videos
06:15Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
Published on: September 7, 2018
06:37Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety
Published on: September 15, 2023
Related Concept Videos
Humoral Immune Responses
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Pharmacodynamics in Geriatric Patients: Effects of Age
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Factors Affecting Protein-Drug Binding: Patient-Related Factors
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...