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Updated: Apr 15, 2026

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
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[Gliaotransmission and brain functions].

Schuichi Koizumi

    Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
    |March 31, 2015
    PubMed
    Summary

    Glial cells, particularly astrocytes, communicate with neurons using gliotransmitters like ATP. Recent advancements in glia-imaging techniques enhance our understanding of these crucial glia-neuron interactions.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Neurochemistry

    Background:

    • Glial cells, including astrocytes, actively participate in neuronal signaling by releasing gliotransmitters.
    • Astrocytes ensheath synaptic structures, enabling direct communication with neurons through gliotransmitters such as ATP, glutamate, and D-serine.

    Purpose of the Study:

    • To review recent advancements in understanding glia-neuron interactions.
    • To highlight the role of astrocytes and the gliotransmitter ATP in synaptic communication.
    • To discuss the impact of novel glia-imaging techniques on studying these interactions.

    Main Methods:

    • Review of current literature on glia-neuron signaling.
    • Focus on astrocyte involvement and ATP as a key gliotransmitter.

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  • Integration of recent developments in glia-imaging technologies.

    • Main Results:

    • Astrocytes are key players in synaptic modulation via gliotransmitter release.
    • ATP is identified as a major gliotransmitter influencing neuronal function.
    • Advanced glia-imaging techniques provide unprecedented insights into glia-neuron communication dynamics.

    Conclusions:

    • Glia-neuron interactions, particularly involving astrocytes and ATP, are fundamental to brain function.
    • Progress in glia-imaging is revolutionizing the study of glial roles in neural circuits.
    • Further research into gliotransmission promises new therapeutic targets for neurological disorders.