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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
[Gestational diabetes and the new screening test's impact]
Ana Catarina Massa1, Ricardo Rangel, Manuela Cardoso
1Serviço de Medicina Materno-Fetal. Maternidade Alfredo da Costa. Centro Hospitalar Lisboa Central. Lisboa. Portugal.
Insights
A new gestational diabetes screening test increased diagnosis rates and led to earlier detection. This resulted in reduced newborn birth weight and fewer large-for-gestational-age infants, improving maternal and perinatal outcomes.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Public Health
Background:
- A revised screening test for gestational diabetes was implemented in 2011 to decrease maternal and perinatal complications.
- The new test aimed for earlier and more widespread diagnosis of gestational diabetes.
Purpose of the Study:
- To evaluate the prevalence of gestational diabetes post-screening test implementation.
- To compare maternal and perinatal outcomes between the old and new screening tests.
- To analyze postpartum screening results following the new test introduction.
Main Methods:
- A retrospective study compared women diagnosed with gestational diabetes in 2009 (n=223) and 2012 (n=237).
- Data collected included demographics, obstetric history, weight gain, gestational age at diagnosis, treatment, neonatal outcomes, and postpartum screening.
- Statistical analysis compared variables between the two study years.
Main Results:
- Gestational diabetes prevalence increased in 2012, with earlier diagnoses (first/second trimester) and reduced pregnancy weight gain.
- Pharmacological therapy use increased significantly (p < 0.001) in 2012.
- Neonatal outcomes showed a significantly lower mean birth weight (p = 0.001) and a decrease in large-for-gestational-age infants (p = 0.002) in 2012.
- Postpartum screening rates were similar, but 2012 saw more normal results and fewer cases of impaired fasting glucose.
Conclusions:
- The updated screening test led to earlier gestational diabetes diagnosis and a reduction in macrosomia.
- Despite increased prevalence, the new criteria appear to mitigate many complications associated with gestational diabetes.
- Further research is needed to address new questions arising from the updated screening protocol.
Introduction:
In 2011, a new screening test for gestational diabetes was introduced which allowed an earlier and larger diagnosis with the goal of reducing maternal and perinatal complications. The aim of our study was to evaluate the prevalence of gestational diabetes, compare maternal and perinatal outcomes with the previous and present screening tests and analyze postpartum screening results.
Material And Methods:
Retrospective study of women with singletons and gestational diabetes diagnosed during 2009 (n = 223) and 2012 (n = 237), at Maternidade Dr. Alfredo da Costa, Portugal. Analysis of clinical charts and assessment of demographic data, medical and obstetric history, weight gain during pregnancy, gestational age at diagnosis, treatment regimens, neonatal outcomes and postpartum screening results, followed by comparison of these variables between the years of 2009 and 2012.
Results:
In 2012, there was an increased gestational diabetes prevalence, lower weight gain during pregnancy (p < 0.001), more frequent use of pharmacological therapy (p < 0.001) and more diagnosed cases during first and second trimester (p < 0.001). As for neonatal outcomes, in this group, the medium weight at birth was significantly lower (p = 0.001) with a decrease of newborns great for gestational age (p = 0.002). Postpartum screening rate was similar among both groups but in 2012 there was an increase of normal results and a decrease of impaired fasting glucose.
Discussion:
Tighter criteria of the current screening test resulted in reduction of the majority of gestational diabetes complications but raised new questions.
Conclusion:
The introduction of the current screening test resulted in an increased prevalence, earlier diagnosis and reduction of macrosomia.
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