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Placental deposition of C-reactive protein is a common feature of human pregnancy

E N Kim1, B H Yoon2, E J Jeon3

  • 1Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea; Asan Laboratory of Perinatal Science, Asan Medical Center, Seoul, Republic of Korea.

Placenta
|March 31, 2015
PubMed

This study examined the occurrence of placental C-reactive protein (CRP) in normal pregnancy with term delivery, spontaneous preterm delivery (sPTD), preeclampsia, and miscarriage. CRP immunoreactivity was detected in the syncytiotrophoblast. The immunopositive rate was significantly higher in sPTD than preeclampsia. The CRP immunopositive rate was also higher in acute chorioamnionitis than those without and showed a good correlation with the maternal serum CRP concentration. CRP mRNA expression was not detected in human and mouse placentas or choriocarcinoma cells. CRP may play a role in the pathological and physiological states of pregnancy.

Keywords:
C-reactive proteinImmunohistochemistryPlacentaTrophoblast

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