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Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
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Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Related Experiment Video

Updated: Apr 15, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Myocardial perfusion imaging using contrast echocardiography.

Faraz Pathan1, Thomas H Marwick1

  • 1Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.

Progress in Cardiovascular Diseases
|March 31, 2015
PubMed
Summary

Microbubble contrast echocardiography offers valuable insights into myocardial perfusion, comparable to nuclear imaging. Despite technical challenges, it holds promise for bedside diagnostics and targeted therapies.

Keywords:
ACSCADCECFRCMRContrast echocardiographyCoronary artery diseaseDSEDiagnosisFDAFood and Drug AdministrationHFLVLV opacificationLVOMBFMBVMIMPMP imagingMPIMechIMyocardial perfusionPETPrognosisRTISPECTTRITissue plasminogen activatoracute coronary syndromecardiac magnetic resonancecontrast echocardiographycoronary artery diseasecoronary flow reservedobutamine stress echocardiographyheart failureleft ventriclemechanical indexmyocardial blood flowmyocardial blood volumemyocardial infarctionmyocardial perfusionpositron emission tomographyreal time imagingsingle photon emission computed tomographytPAtriggered replenishment imaging

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Area of Science:

  • Cardiovascular Imaging
  • Diagnostic Ultrasound
  • Medical Diagnostics

Background:

  • Microbubbles serve as effective intravascular tracers for assessing myocardial perfusion.
  • Myocardial opacification rate and contrast intensity provide unique data on coronary microvascular perfusion and myocardial blood volume.
  • Existing evidence supports the comparability of microbubble imaging with nuclear perfusion imaging.

Purpose of the Study:

  • To highlight the diagnostic and prognostic value of microbubble contrast echocardiography.
  • To emphasize the potential for bedside measurement of myocardial perfusion.
  • To discuss the challenges and future prospects of this imaging modality.

Main Methods:

  • Utilizing microbubbles as intravascular contrast agents.
  • Analyzing myocardial opacification rate (coronary microvascular perfusion) and contrast intensity (myocardial blood volume).
  • Comparing results with nuclear perfusion imaging and wall motion analysis.

Main Results:

  • Microbubble imaging demonstrates comparability with nuclear perfusion imaging.
  • The technique offers incremental diagnostic and prognostic value beyond wall motion analysis.
  • Myocardial perfusion can potentially be measured at the bedside using this method.

Conclusions:

  • Microbubble contrast echocardiography provides unique insights into myocardial perfusion.
  • Despite technical and logistical hurdles, the modality holds significant promise.
  • Future development in targeted interventions may revive interest in microbubble imaging.