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Asymmetrical Ovarian Enlargement: Caught Timely Before the Cut!
Nikhil M Bhagwat1, Pradip P Dalwadi1, Ameya S Joshi1
1Department of Endocrinology, B.Y.L. Nair Charitable Hospital and Topiwala National Medical College, Mumbai Central, Mumbai, India.
Journal of Pediatric and Adolescent Gynecology
|March 31, 2015
Summary
Van Wyk-Grumbach syndrome, a rare condition causing precocious puberty and ovarian enlargement in girls with hypothyroidism, is reversible. Prompt treatment with levothyroxine can normalize ovarian function and prevent surgery.
Area of Science:
- Pediatric Endocrinology
- Reproductive Endocrinology
- Thyroid Disorders
Background:
- Van Wyk-Grumbach syndrome is a rare complication of untreated primary hypothyroidism.
- It presents with precocious puberty and enlarged multicystic ovaries.
- Early diagnosis and treatment are crucial to avoid unnecessary surgeries.
Observation:
- A 12-year-old girl experienced recurrent abdominal pain.
- Ultrasonography revealed bilateral ovarian enlargement.
- Severe hypothyroidism was diagnosed, with negative ovarian tumor markers.
Findings:
- The patient was treated with levothyroxine.
- Thyroid function normalized within one year.
- Ovarian volume regressed to normal sizes.
Implications:
- Levothyroxine therapy can effectively reverse ovarian enlargement in Van Wyk-Grumbach syndrome.
- This highlights the importance of recognizing and managing hypothyroidism in pediatric patients.
- Timely medical intervention prevents the need for surgical procedures for ovarian issues related to hypothyroidism.