Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

34.3K
Overview
34.3K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

224
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
224
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

176
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
176
Hypersensitivities01:30

Hypersensitivities

8.6K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.6K
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

3.5K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.5K
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

268
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
268

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diet-Microbiome-Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications.

Allergy·2026
Same author

Pregnancy in Women with Atopic Dermatitis: A Systematic Review of Concerns and Challenges.

Acta dermato-venereologica·2026
Same author

The definition of response and inadequate response to topical corticosteroid treatment in atopic dermatitis and related skin inflammatory diseases: A GA<sup>2</sup>LEN ADCARE statement paper.

The World Allergy Organization journal·2026
Same author

Proteomic analysis of horse hair extracts provides no evidence for the existence of a hypoallergenic Curly Horse breed.

Clinical and translational allergy·2026
Same author

Hypersensitivity to Excipients in Drugs: An EAACI Position Paper.

Allergy·2026
Same author

Atopic Dermatitis in Denmark: Regional Variation.

Acta dermato-venereologica·2026

Related Experiment Video

Updated: Apr 15, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.8K

Decrease in the rate of sensitization and clinical allergy to natural rubber latex.

Michelle S B Blaabjerg1, Klaus E Andersen1, Carsten Bindslev-Jensen1,2

  • 1Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, DK-5000, Odense C, Denmark.

Contact Dermatitis
|March 31, 2015
PubMed
Summary
This summary is machine-generated.

Natural rubber latex (NRL) allergy prevalence significantly decreased from 2002 to 2013. Many NRL-sensitized individuals without clinical allergy showed co-existing birch pollen sensitization and food-related symptoms.

Keywords:
allergybirch pollen sensitizationfood allergynatural rubber latexprevalencesensitization

More Related Videos

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.3K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.1K

Related Experiment Videos

Last Updated: Apr 15, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.8K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.3K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.1K

Area of Science:

  • Allergy and Immunology
  • Dermatology
  • Epidemiology

Background:

  • Natural rubber latex (NRL) allergy cases increased notably in the 1980s.
  • Preventive measures for NRL allergy have been implemented since the rise in cases.

Purpose of the Study:

  • To assess temporal trends in NRL sensitization and clinical allergy prevalence.
  • The study period spanned from 2002 to 2013.

Main Methods:

  • A cohort of 8580 patients undergoing NRL prick testing was analyzed.
  • Clinical relevance of NRL sensitization was evaluated.
  • Concomitant birch pollen sensitization and food-related symptoms were recorded in a subgroup.

Main Results:

  • NRL sensitization prevalence dropped from 6.1% (2002-2005) to 1.2% (2010-2013).
  • Clinical NRL allergy prevalence decreased from 1.3% to 0.5-0.6% during the study period.
  • 64% of NRL-sensitized patients had birch pollen sensitization; 52% reported reactions to related foods.

Conclusions:

  • A significant decline in NRL sensitization and clinical allergy was observed.
  • Birch pollen sensitization and food-related symptoms were common in NRL-sensitized patients without clinical NRL allergy.