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Updated: Apr 15, 2026
Establishment and Evaluation of a Porcine Vein Graft Disease Model
Published on: July 25, 2022
Association Between Platelet to Lymphocyte Ratio and Saphenous Vein Graft Disease
Çağrı Yayla1, Uğur Canpolat2, Ahmet Akyel3
1Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Insights
The platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) are higher in patients with saphenous vein graft disease (SVGD). These markers independently predict SVGD, offering new insights into cardiovascular risk assessment.
Area of Science:
- Cardiovascular Research
- Hematology
- Vascular Surgery
Background:
- Atherosclerosis is a key factor in saphenous vein graft disease (SVGD).
- Inflammatory blood cells are implicated in the pathogenesis of SVGD.
- The platelet to lymphocyte ratio (PLR) is a potential biomarker for cardiovascular risk and atherosclerosis.
Purpose of the Study:
- To investigate the association between SVGD and PLR.
- To evaluate PLR and MPV as predictors of SVGD.
Main Methods:
- A cohort of 220 patients with saphenous vein grafts (SVGs) was analyzed.
- Patients were categorized into groups with and without SVGD (defined by ≥50% stenosis).
- Statistical analyses, including multivariate logistic regression, were performed.
Main Results:
- Median PLR and mean platelet volume (MPV) were significantly elevated in patients with SVGD.
- PLR correlated positively with SVG age, which was also higher in the SVGD group.
- PLR and MPV were identified as independent predictors of SVGD.
Conclusions:
- This study demonstrates, for the first time, an independent association between PLR and SVGD.
- PLR and MPV may serve as valuable predictive markers for saphenous vein graft disease.
Abstract:
Atherosclerosis plays an important role in saphenous vein graft disease (SVGD). Previous trials showed that inflammatory blood cells play a role in this process. The platelet to lymphocyte ratio (PLR) has been proposed as a novel predictor for cardiovascular risk and indicator of atherosclerosis. The aim of this study was to assess the relationship between SVGD and PLR. A total of 220 patients with SVG were enrolled (n = 87 with SVGD and n = 133 with patent SVG). A ≥ 50% stenosis within the SVG was defined as clinically significant. Median PLR (P < .001) and mean platelet volume (MPV; P = .043) were significantly higher in patients with SVGD. Also, PLR showed significantly positive correlation with age of SVG (P < .05). Median age of SVGs was also higher in the SVGD group (P = .025). In multivariate logistic regression analyses, the PLR and MPV were independent predictors of SVGD. Using a cutoff level of 106.3, the PLR predicted SVGD with a sensitivity of 87.4% and a specificity of 80.3%. To the best of our knowledge, this study showed, for the first time, that PLR was independently associated with SVGD. Both PLR and MPV might predict SVGD.
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