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Updated: Apr 15, 2026

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
Published on: September 16, 2020
The multifaceted mitochondrion: An attractive candidate for therapeutic strategies
Flavie Strappazzon1, Francesco Cecconi2
1IRCCS Fondazione Santa Lucia, 00143 Rome, Italy; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
Abstract:
Mitochondria are considered the powerhouse of the cell and disturbances in mitochondrial functions are involved in several disorders such as neurodegeneration and mitochondrial diseases. This review summarizes pharmacological strategies that aim at modifying the number of mitochondria, their dynamics or the mitochondrial quality-control mechanisms, in several pathological instances in which any of these mechanisms are impaired or abnormal. The interplay between different cellular pathways that involve mitochondria in order to respond to stress is highlighted. Such a high mitochondrial plasticity could be exploited for new treatments.
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