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Hypercoagulability in dogs with blastomycosis
M A McMichael1, M O'Brien, S A Smith
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Illinois, Urbana, IL.
Journal of Veterinary Internal Medicine
|March 31, 2015
Summary
Dogs with blastomycosis exhibit hypercoagulability, a state of increased blood clotting. This finding suggests that blood clot formation may contribute to the severe symptoms observed in this fungal infection.
Area of Science:
- Veterinary Medicine
- Mycology
- Hematology
Background:
- Blastomycosis is a serious fungal infection affecting humans and dogs, primarily targeting the lungs.
- Systemic inflammation from blastomycosis may induce a hypercoagulable state, potentially impairing oxygen exchange through pulmonary microemboli.
Purpose of the Study:
- To determine if dogs diagnosed with blastomycosis display hypercoagulability compared to healthy controls.
- To investigate the hemostatic changes associated with blastomycosis in dogs.
Main Methods:
- A prospective case-controlled study involving 23 client-owned dogs with blastomycosis and 23 healthy controls.
- Evaluated complete blood counts, fibrinogen, prothrombin time (PT), activated partial thromboplastin time (aPTT), thromboelastometry (TE), thrombin antithrombin complexes (TAT), and thrombin generation.
Main Results:
- Dogs with blastomycosis showed significantly higher white blood cell counts, hyperfibrinogenemia, and elevated TAT concentrations compared to controls.
- Thromboelastometry and calibrated automated thrombography revealed a hypercoagulable state and increased thrombin generation in dogs with blastomycosis.
Conclusions:
- Systemic blastomycosis in dogs is associated with a hypercoagulable state.
- Further research is warranted to investigate the role of thrombogenicity in the clinical presentation of systemic blastomycosis.
