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Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

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Published on: September 7, 2018

Hypercoagulability in dogs with blastomycosis.

M A McMichael¹, M O'Brien, S A Smith

¹Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Illinois, Urbana, IL.

Journal of Veterinary Internal Medicine

|March 31, 2015

Summary

This summary is machine-generated.

Dogs with blastomycosis exhibit hypercoagulability, a state of increased blood clotting. This finding suggests that blood clot formation may contribute to the severe symptoms observed in this fungal infection.

Keywords:

Canine Thromboelastography Thromboelastometry Thrombosis

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Area of Science:

Veterinary Medicine
Mycology
Hematology

Background:

Blastomycosis is a serious fungal infection affecting humans and dogs, primarily targeting the lungs.
Systemic inflammation from blastomycosis may induce a hypercoagulable state, potentially impairing oxygen exchange through pulmonary microemboli.

Purpose of the Study:

To determine if dogs diagnosed with blastomycosis display hypercoagulability compared to healthy controls.
To investigate the hemostatic changes associated with blastomycosis in dogs.

Main Methods:

A prospective case-controlled study involving 23 client-owned dogs with blastomycosis and 23 healthy controls.
Evaluated complete blood counts, fibrinogen, prothrombin time (PT), activated partial thromboplastin time (aPTT), thromboelastometry (TE), thrombin antithrombin complexes (TAT), and thrombin generation.

Main Results:

Dogs with blastomycosis showed significantly higher white blood cell counts, hyperfibrinogenemia, and elevated TAT concentrations compared to controls.
Thromboelastometry and calibrated automated thrombography revealed a hypercoagulable state and increased thrombin generation in dogs with blastomycosis.

Conclusions:

Systemic blastomycosis in dogs is associated with a hypercoagulable state.
Further research is warranted to investigate the role of thrombogenicity in the clinical presentation of systemic blastomycosis.