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Updated: Apr 15, 2026

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Onartuzumab in lung cancer: the fall of Icarus?

Christian Rolfo1, Nele Van Der Steen, Patrick Pauwels

  • 1Oncology Department, Phase I - Early Clinical Trials Unit, Antwerp University Hospital, Edegem, Belgium.

Expert Review of Anticancer Therapy
|March 31, 2015
PubMed

Insights

Targeted therapies revolutionize non-small-cell lung cancer treatment, but reliable biomarkers and flexible clinical trial designs are crucial for drug approval. The failed MetLung trial highlights these challenges.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Trial Design

Background:

  • Targeted therapies have transformed non-small-cell lung cancer (NSCLC) treatment, advancing personalized medicine.
  • Numerous novel inhibitors are emerging due to the discovery of new molecular targets.
  • There is a critical need for reliable biomarkers to guide targeted therapy selection and predict patient response.
Keywords:
Phase Ic-METnon-small-cell lung cancerornatuzumabtrial design

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