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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
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S100 protein in breast tumor
1Department of Internal Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300052, China.
Indian Journal of Cancer
|March 31, 2015
Summary
S100 proteins, linked to breast tumors, play a role in cancer metastasis. Understanding their expression aids in diagnosing and predicting outcomes for breast cancer patients.
Area of Science:
- Biochemistry
- Oncology
- Molecular Biology
Background:
- S100 proteins are a large family of calcium-binding proteins.
- Abnormal S100 protein expression is frequently associated with various cancers, including breast tumors.
- Breast cancer is a leading cause of mortality in women, often driven by metastasis.
Purpose of the Study:
- To review the expression patterns of S100 proteins in breast tumors.
- To investigate the impact of S100 proteins on breast tumor metastasis.
- To evaluate the prognostic significance of S100 proteins in breast cancer.
Main Methods:
- Literature review of recent research on S100 proteins and breast cancer.
- Analysis of studies examining S100 protein expression levels.
- Synthesis of data on the correlation between S100 proteins and tumor metastasis and patient prognosis.
Main Results:
- S100 proteins exhibit altered expression in breast tumors.
- Specific S100 proteins are implicated in promoting breast tumor development and metastasis.
- Expression levels of certain S100 proteins correlate with patient prognosis.
Conclusions:
- S100 proteins are significant factors in breast tumor progression and metastasis.
- S100 proteins may serve as potential diagnostic and prognostic biomarkers for breast cancer.
- Further research into S100 protein functions can inform therapeutic strategies.
