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[Peripheral blood apelin level in patients with acute ST-elevation myocardial infarction and its prognostic value]

Jian Shen1, Xu Zhang, Zhiming Li

  • 1Department of Cardiovascular Diseases, Huizhou Municipal Central Hospital, Huizhou 516001, China.E-mail: alberten@163.com.

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|March 31, 2015
PubMed

Insights

Peripheral blood apelin levels were lower in patients with ST-elevation myocardial infarction (STEMI) but did not predict one-year outcomes. Further research is needed to clarify apelin

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • ST-elevation myocardial infarction (STEMI) is a critical condition requiring prompt intervention.
  • Apelin, a peptide hormone, plays a role in cardiovascular function.
  • Understanding biomarkers for STEMI prognosis is crucial for patient management.

Purpose of the Study:

  • To examine peripheral blood apelin levels in acute STEMI patients.
  • To assess the correlation between apelin levels and one-year clinical outcomes post-STEMI.

Main Methods:

  • A cohort of 153 patients (93 acute STEMI, 30 stable angina, 30 STEMI controls) and 10 healthy subjects were analyzed.
  • Peripheral blood apelin levels and clinical parameters were measured.
  • One-year composite endpoints were evaluated.

Main Results:

  • Apelin levels were significantly reduced at admission in STEMI patients, increasing post-primary percutaneous coronary intervention (PCI).
  • Lower apelin levels correlated with increased risk of reduced left ventricular ejection fraction at one year.
  • Apelin levels did not prove to be predictive of one-year outcomes in STEMI patients.

Conclusions:

  • Peripheral blood apelin levels may offer insights into STEMI patient clinical outcomes.
  • Further investigation is warranted to establish apelin's definitive role in predicting STEMI prognosis.
Abstract

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