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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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[Management of side effects of targeted therapies in renal cancer: cutaneous side effects]

Caroline Robert1, Pierre Gimel2

  • 1Institut Gustave-Roussy, service de dermatologie, 39, rue Camille-Desmoulins, 94805 Villejuif Cedex, France.

Bulletin Du Cancer
|March 31, 2015
PubMed

Insights

Targeted cancer therapies, including angiogenesis and mTOR inhibitors, can cause skin, hair, and nail side effects in advanced renal cell carcinoma patients. This guideline details managing these common dermatologic reactions.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Context:

  • Advanced renal cell carcinoma (RCC) treatment often involves targeted therapies.
  • Angiogenesis inhibitors and mTOR inhibitors are key targeted therapies for advanced RCC.
  • These therapies can cause significant dermatologic adverse events.

Purpose:

  • To describe the incidence and clinical presentation of skin, hair, and nail side effects.
  • To provide treatment guidelines for managing these dermatologic reactions.
  • To inform clinicians on managing side effects from specific targeted therapies like sunitinib, sorafenib, pazopanib, bevacizumab, everolimus, and temsirolimus.

Summary:

  • Targeted therapies for advanced renal cell carcinoma frequently cause dermatologic side effects.
  • Common reactions affect the skin, hair, and nails.
  • Management strategies for these side effects are outlined.

Impact:

  • Improved patient quality of life during cancer treatment.
  • Enhanced adherence to necessary targeted therapies.
  • Better understanding and management of drug-induced dermatologic conditions in oncology.
Keywords:
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