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Updated: Apr 15, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
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A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

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Mortality, sudden death and indication for cardioverter defibrillator implantation in a dialysis population

Simonetta Genovesi1, Luca Porcu2, Maria Carmen Luise3

  • 1Nephrology Unit, San Gerardo Hospital, Monza, Italy; Department of Health Sciences, University of Milan-Bicocca, Italy.

International Journal of Cardiology
|March 31, 2015
PubMed

Insights

Sudden death is common in dialysis patients. Implantable cardioverter defibrillators (ICDs) may not improve survival in this population, with high sudden death rates even in those without an ICD indication.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Trials

Background:

  • Sudden death is a significant concern in patients undergoing dialysis.
  • End-stage renal disease (ESRD) was previously an exclusion criterion in trials evaluating implantable cardioverter defibrillators (ICDs).

Purpose of the Study:

  • To evaluate the impact of ICDs on mortality in dialysis patients.
  • To assess the incidence of sudden death in dialysis patients with and without ICD indications.

Main Methods:

  • Retrospective evaluation of dialysis patients from January 2010 to January 2013.
  • Patients categorized into No-Indication, Indication-With ICD, and Indication-Without ICD groups.
  • Cox and Fine-Gray regression models used for mortality and cause-specific mortality analysis.

Main Results:

  • 7.4% of patients had an ICD indication, with 33.8% receiving a device.
  • Overall mortality was higher in patients with an ICD indication compared to those without.
  • Sudden death incidence was significantly elevated in patients with an ICD indication, and also high in the No-Indication group.

Conclusions:

  • Dialysis patients with an ICD indication exhibit poorer survival rates.
  • The prognosis is particularly grim for dialysis patients with an ICD indication but without the device.
  • Sudden death rates are substantially higher in the dialysis population compared to the general population.
Abstract

Keywords:
End stage renal diseaseHemodialysisImplantable cardioverter defibrillatorMortalitySudden death

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