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NT pro B type natriuretic peptide levels in constrictive pericarditis and restrictive cardiomyopathy

Neeraj Parakh1, Sameer Mehrotra2, Sandeep Seth1

  • 1Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

Indian Heart Journal
|March 31, 2015
PubMed

Insights

N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels can help differentiate constrictive pericarditis (CP) from restrictive cardiomyopathy (RCM). NT-pro-BNP is significantly higher in RCM patients, aiding in diagnosis.

Area of Science:

  • Cardiology
  • Biomarkers
  • Diagnostic Medicine

Background:

  • Differentiating constrictive pericarditis (CP) from restrictive cardiomyopathy (RCM) presents clinical challenges.
  • Brain natriuretic peptide (BNP) levels are higher in RCM than CP, but clinical utility requires further study, especially in Indian populations with advanced CP.

Purpose of the Study:

  • To evaluate the diagnostic utility of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) in distinguishing between CP and RCM.
  • To establish NT-pro-BNP as a reliable biomarker for differentiating these two cardiac conditions.

Main Methods:

  • Measured NT-pro-BNP levels in 49 patients with suspected CP or RCM.
  • Utilized echocardiography, CT, MRI, endomyocardial biopsy, and cardiac catheterization for diagnosis.
  • Analyzed NT-pro-BNP levels in 29 CP patients (mean age 26) and 20 RCM patients (mean age 39).

Main Results:

  • Median plasma NT-pro-BNP levels were significantly higher in RCM [1775 pg/ml] compared to CP [124 pg/ml] (p=0.001).
  • A cutoff value of 459 pg/ml demonstrated 90% sensitivity, 86% specificity, and 88% overall accuracy for differentiating CP from RCM.

Conclusions:

  • NT-pro-BNP levels are significantly elevated in RCM compared to CP.
  • NT-pro-BNP is a valuable biomarker for differentiating RCM from CP, with high diagnostic accuracy.
Abstract

Keywords:
Constrictive pericarditisNT pro-BNPRestrictive cardiomyopathy

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