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Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
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Determinants of Muscle and Bone Aging.
Elizabeth Curtis1, Anna Litwic1, Cyrus Cooper1
1MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Tremona Road, Southampton, England.
Journal of Cellular Physiology
|March 31, 2015
Summary
Aging bone and muscle loss threaten independence. Osteoporosis and sarcopenia increase fracture and fall risks, highlighting the need for interventions targeting muscle quality and aging factors.
Area of Science:
- Gerontology and musculoskeletal health.
Background:
- Advancing age leads to bone and muscle loss, increasing risks of osteoporosis, fragility fractures, and sarcopenia.
- Sarcopenia, or age-related muscle mass and function decline, exacerbates fracture risk by increasing falls.
- Muscle aging involves more than mass loss; factors like composition, metabolism, and neural activation also impact muscle quality.
Purpose of the Study:
- To review factors influencing age-related bone and muscle loss.
- To discuss the interplay of genetic, environmental, and lifestyle factors on musculoskeletal health.
- To explore emerging research areas like inflammaging for potential interventions.
Main Methods:
- Literature review of factors affecting bone and muscle mass in aging.
- Analysis of genetic, developmental, endocrine, and lifestyle influences.
- Consideration of early environmental impacts and inflammaging.
Main Results:
- Age-related bone and muscle loss significantly impact independence and increase fracture/fall risks.
- Multiple factors beyond muscle mass, including metabolic and neural aspects, determine muscle quality.
- Lifestyle, genetics, and early environment play crucial roles in musculoskeletal aging.
Conclusions:
- Interventions targeting bone and muscle loss are vital for maintaining independence in older adults.
- A holistic approach considering muscle quality, genetics, lifestyle, and environment is necessary.
- Emerging research, including inflammaging, offers promising avenues for future therapeutic strategies.
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