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Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins
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Muc5ac mucin expression during rat skin development.

V Ferretti1, Á Segal-Eiras, C G Barbeito

  • 1National University of La Plata. crocevir@hotmail.com.

European Journal of Histochemistry : EJH
|March 31, 2015
PubMed
Summary
This summary is machine-generated.

Muc5ac mucin expression was detected in developing rat skin, suggesting a protective role before birth. This protective function may be replaced by fur covering after birth.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Dermatology

Background:

  • Mucin gene expression is known in human embryonic organ development.
  • Mucin expression in epidermal development is poorly understood in all species.
  • This study investigates mucin expression in skin development.

Purpose of the Study:

  • To explore Muc5ac skin expression during prenatal and postnatal rat development.
  • To determine the role of Muc5ac in embryonic skin.
  • To establish the timeline of Muc5ac expression in rat skin.

Main Methods:

  • Immunohistochemistry (IHC) was used to visualize Muc5ac protein.
  • Western blotting (WB) was employed to detect Muc5ac protein.
  • RT-PCR confirmed gene expression levels.

Main Results:

  • Muc5ac protein was detected in embryonic epidermis from gestation day 13.
  • Protein expression persisted until seven days post-birth, then localized to sebum cells.
  • WB and RT-PCR results corroborated IHC findings.

Conclusions:

  • Muc5ac expression in embryonic rat epidermis suggests a protective role.
  • This role may be superseded by fur covering postnatally.
  • This is the first report confirming Muc5ac expression during skin development.