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Related Experiment Video

Updated: Apr 15, 2026

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Central and peripheral irisin differentially regulate blood pressure.

Weizhen Zhang1, Lin Chang, Chao Zhang

  • 1Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, Ann Arbor, MI, 48109, USA, weizhenz@umich.edu.

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Central irisin boosts blood pressure and heart function, while peripheral irisin lowers it. This hormone, irisin, shows differential cardiovascular regulation depending on its administration site.

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Area of Science:

  • Endocrinology
  • Cardiovascular Physiology
  • Neuroendocrinology

Background:

  • Irisin, a hormone derived from FNDC5, is linked to metabolic activity in muscle and fat.
  • The impact of irisin on cardiovascular functions remains largely unexplored.

Purpose of the Study:

  • To investigate the cardiovascular effects of both central and peripheral irisin administration.
  • To elucidate the differential roles of irisin in regulating blood pressure and cardiac contractility.

Main Methods:

  • Recombinant human irisin was administered centrally (3rd brain ventricle) or peripherally (intravenously) in rats.
  • Measurements included blood pressure, cardiac contractility, and mesenteric artery ring dilation.
  • Effects were assessed in both control and spontaneously hypertensive rat models.

Main Results:

  • Central irisin administration activated hypothalamic neurons and increased blood pressure and cardiac contractility.
  • Central irisin reversed atenolol-induced cardiac dysfunction.
  • Peripheral irisin administration decreased blood pressure and dilated mesenteric arteries via ATP-sensitive potassium channels.

Conclusions:

  • Central and peripheral administration of irisin exert opposing effects on cardiovascular parameters.
  • Irisin demonstrates a dual role in cardiovascular regulation, highlighting site-specific actions.