Related Experiment Video
Updated: Apr 15, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Pentoxifylline-tocopherol-clodronate combination: A novel treatment for osteoradionecrosis of the temporal bone
Jordan T Glicksman1, Sammy Khalili1, Kevin Fung1
1Department of Otolaryngology, Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Background:
Osteoradionecrosis (ORN) of the temporal bone is a complication of radiation therapy that is extremely challenging to manage.
Methods:
We report the case of a patient treated at our institution and present a review of the literature.
Results:
A 52-year-old woman presented with ORN of the temporal bone 20 years after radiation therapy for an ipsilateral parotid tumor. She failed conservative management, including serial debridements, oral and topical antibiotics/antifungals, and aural lavage. As an alternative to hyperbaric oxygen (HBO) and/or temporal bone resection, treatment with pentoxifylline-tocopherol-clodronate combination (PENTOCLO) was pursued and her condition improved dramatically.
Conclusion:
This is the first document use of PENTOCLO to treat ORN of the temporal bone. PENTOCLO may represent an effective nonsurgical management option for ORN of the temporal bone.
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