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DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
Adriana Sierra Assencio Almeida Barbosa1, Larissa Ragozo Cardoso de Oliveira2, Francilene Capel Tavares2
1Biology Technical Team, Lauro de Souza Lima Institute, Bauru, São Paulo State Brazil ; Equipe Técnica de Biologia, Instituto Lauro de Souza Lima, Rod. Comte. João Ribeiro de Barros, km 225/226, CEP 17.034-971 Bauru, SP Brazil.
Background:
Jorge Lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.
Methods:
DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).
Results:
The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.
Conclusion:
These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
