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Macrophage migration inhibitory factor polymorphism is associated with susceptibility to inflammatory coronary heart

Kangting Ji1, Xiaoyan Wang1, Ji Li2

  • 1Department of Cardiology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China.

Biomed Research International
|March 31, 2015
PubMed
Abstract

Insights

The 173G/C polymorphism in the macrophage migration inhibitory factor (MIF) gene is associated with coronary heart disease (CHD) in a Chinese population. Higher plasma MIF levels predict plaque instability in CHD patients.

Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Disease Research
  • Immunology

Background:

  • Macrophage migration inhibitory factor (MIF) is a key proinflammatory cytokine.
  • Genetic variations, specifically the 173G/C polymorphism in the MIF gene, are investigated for their role in disease development.
  • Coronary heart disease (CHD) is a significant global health concern with complex genetic and environmental factors.

Purpose of the Study:

  • To investigate the association between the MIF gene 173G/C polymorphism and the risk of developing coronary heart disease (CHD).
  • To evaluate the relationship between plasma MIF levels, MIF gene polymorphism, and clinical presentation (stable vs. unstable angina) in CHD patients.
  • To determine if plasma MIF levels can serve as a predictor of plaque stability in individuals with CHD.

Main Methods:

  • DNA sequencing was performed on 186 healthy controls and 70 CHD patients to identify MIF gene genotypes.
  • Plasma MIF levels were quantified using ELISA upon patient admission.
  • Statistical analysis was employed to compare genotype frequencies between cases and controls and to assess associations with MIF levels and plaque stability.

Main Results:

  • The frequency of the MIF 173*C and 173*CC genotypes was significantly higher in CHD patients compared to controls.
  • Plasma MIF levels were elevated in both CHD patients overall and specifically in carriers of the MIF 173*C allele.
  • Unstable angina pectoris (UAP) patients exhibited higher plasma MIF levels than those with stable angina pectoris (SAP).

Conclusions:

  • The MIF -173G/C polymorphism is potentially linked to the pathogenesis of CHD in the studied Chinese population.
  • Elevated plasma MIF levels are identified as a significant predictor of plaque instability in patients with coronary heart disease.
  • This research provides insights into the genetic and molecular mechanisms underlying CHD development and progression.

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