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The physiologic interferon response. VI. Interferon activity in human plasma after a meal and drinking
Lymphokine Research
|January 1, 1985
Summary
Plasma interferon (IFN) activity shows a slight afternoon increase, potentially linked to digestion and lymphatic drainage. This suggests a possible circadian rhythm and localized IFN-alpha production.
Area of Science:
- Immunology
- Physiology
Background:
- Interferon (IFN) activity in plasma exhibits diurnal variations.
- Understanding the physiological regulation of IFN is crucial for immunology.
Purpose of the Study:
- To investigate the potential circadian rhythm of plasma interferon activity.
- To explore factors influencing afternoon increases in interferon levels.
Main Methods:
- Assessed plasma interferon activity at different times of day.
- Correlated IFN levels with meal intake and hydration.
- Characterized the type of interferon involved (acid-labile IFN-alpha).
Main Results:
- Plasma IFN activity was negligible in the morning and slightly increased in the afternoon.
- This diurnal difference was not statistically significant due to high variability.
- IFN activity was attributed to acid-labile IFN-alpha.
- Postprandial increases in IFN levels were observed after fatty meals or water intake.
Conclusions:
- A possible circadian rhythm of IFN activity exists, though not statistically confirmed.
- Increased abdominal lymphatic drainage post-digestion may contribute to afternoon IFN elevation.
- Findings indirectly support a physiological IFN response with localized lymphomonokine production and limited systemic circulation.