Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Serum desmosine served as a biomarker for severity and prognosis in COVID-19 patients.

BMC pulmonary medicine·2026

Same author

Computational pharmacovigilance of tranexamic acid: implications for intracerebral hemorrhage based on FAERS database and network toxicology.

Frontiers in pharmacology·2026

Same author

Large-scale integrated optoelectronic chaos for machine learning acceleration.

Nature communications·2026

Same author

CXCL8 Enhances Malignancy of GBM via TNFα-NFκB Mediated Suppression of Ferroptosis.

Applied biochemistry and biotechnology·2026

Same author

SYVN1-provoked RASA1 ubiquitination promotes pulmonary inflammation in chronic obstructive pulmonary disease.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026

Same author

Psychological phenotypes of sense of coherence: How illness perception mediates distress differently across patient subgroups with hematologic malignancies.

Acta psychologica·2026

Search research articles

Related Experiment Video

Updated: Apr 15, 2026

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Prefrontal dysfunction and a monkey model of schizophrenia.

Ping Mao¹, Ding Cui, Xu-Dong Zhao

¹Kunming General Hospital of Chengdu Military Command, Kunming, 650032, China.

Neuroscience Bulletin

|March 31, 2015

Summary

Schizophrenia involves prefrontal cortex dysfunction and cognitive deficits. A monkey model using phencyclidine (PCP) mimics these symptoms, which are improved by clozapine, suggesting it may indicate schizophrenia-related cognitive impairment.

More Related Videos

Operant Procedures for Assessing Behavioral Flexibility in Rats

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Published on: March 22, 2016

Related Experiment Videos

Last Updated: Apr 15, 2026

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Operant Procedures for Assessing Behavioral Flexibility in Rats

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Published on: March 22, 2016

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Prefrontal cortex dysfunction is linked to schizophrenia symptoms and cognitive disorders.
Schizophrenia patients exhibit cognitive impairments alongside typical symptoms.

Purpose of the Study:

To create a non-human primate model for schizophrenia-related cognitive impairment.
To investigate the efficacy of atypical antipsychotics in this model.

Main Methods:

Induction of schizophrenia-like cognitive symptoms in monkeys using phencyclidine (PCP), an N-methyl-D-aspartate receptor antagonist.
Administration of clozapine, an atypical antipsychotic, to assess behavioral improvements.

Main Results:

Phencyclidine administration successfully induced cognitive deficits in the monkey model.
Clozapine treatment ameliorated the PCP-induced behavioral impairments.

Conclusions:

The monkey model effectively mimics cognitive symptoms of schizophrenia.
The beneficial effect of clozapine suggests its potential as an indicator for schizophrenia-related cognitive impairment.