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The association of first trimester bleeding with preterm delivery

Iwona Szymusik, Pawel Bartnik, Klaudia Wypych

    Journal of Perinatal Medicine
    |March 31, 2015
    PubMed

    Insights

    First trimester bleeding (FTB) significantly increases the risk of preterm birth (PTB) and associated pregnancy complications. Early screening for PTB and placental issues is crucial for managing FTB pregnancies.

    Area of Science:

    • Obstetrics and Gynecology
    • Maternal-Fetal Medicine
    • Perinatal Health

    Background:

    • Preterm birth (PTB) is a major cause of perinatal morbidity and mortality, incurring significant healthcare costs.
    • First trimester bleeding (FTB) is known to be associated with PTB, but its impact on PTB severity requires further investigation.

    Purpose of the Study:

    • To analyze the influence of FTB on the risk and severity of PTB.
    • To assess the association between FTB and other pregnancy complications.

    Main Methods:

    • Observational case-control study design.
    • Utilized medical records of 997 women who delivered between 2010 and 2013.
    • Compared outcomes between 497 women with FTB and 500 women without FTB.

    Main Results:

    • Women with FTB had a significantly higher likelihood of delivering preterm (OR=2.11).
    • FTB was associated with a nearly four-fold increased risk of extremely preterm birth (<28 weeks) and a more than three-fold risk of very preterm birth (28-31 weeks).
    • FTB also increased the risk of placenta previa (OR=4.81).

    Conclusions:

    • FTB is identified as a significant risk factor for preterm birth.
    • FTB is associated with an increased risk of PTB-related pregnancy complications, including placenta previa.
    • Management of pregnancies with FTB should involve comprehensive screening for preterm delivery and placental abnormalities.
    Abstract

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