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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
[Autoimmune hepatitis preceded by hepatitis A]
Anne Grave1, Jacob Juel, Mogens Vyberg
1Medicinsk Gastroenterologisk Afdeling, Aalborg Universitetshospital, Mølleparkvej 4, 9000 Aalborg. anne.grave@studmed.au.dk.
Abstract:
Autoimmune hepatitis is characterized by unresolving inflammation and fibrosis of the liver, which untreated may lead to cirrhosis. The pathogenesis remains unclear and reflects a complex interaction between autoantigens, genetic predisposition, triggering factors and immune regulation. In rare cases, acute hepatitis A has been suspected as a triggering factor. We describe a case of a 66-year-old woman who two months after a resolving acute hepatitis A presented with fatigue, pale stools and elevated levels of transaminases. A liver biopsy showed histological changes compatible with autoimmune hepatitis.
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