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Growth of Cartilage and Bone Tissue01:27

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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Related Experiment Video

Updated: Apr 15, 2026

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage
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[Morphological and functional cartilage imaging].

C Rehnitz1, M-A Weber

  • 1Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Heidelberg, Deutschland, Christoph.Rehnitz@med.uni-heidelberg.de.

Der Orthopade
|March 31, 2015
PubMed
Summary
This summary is machine-generated.

Modern MRI techniques offer excellent cartilage imaging for detecting subtle pathologies and early osteoarthritis. Advanced 3D sequences and functional imaging methods like dGEMRIC, T2 mapping, and gagCEST enable detailed assessment of cartilage composition and therapeutic response.

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Area of Science:

  • Radiology
  • Biomedical Engineering
  • Orthopedics

Background:

  • High-resolution cartilage imaging is crucial for detecting subtle pathologies.
  • Both 2D and 3D MRI sequences offer advanced morphological imaging capabilities.
  • Functional imaging is essential for assessing cartilage composition and early osteoarthritis.

Purpose of the Study:

  • To review modern morphological imaging techniques for cartilage.
  • To discuss functional imaging methods for detecting cartilage composition changes.
  • To evaluate techniques for monitoring biochemical changes after therapeutic interventions.

Main Methods:

  • Utilizing advanced 3D MRI sequences for high-resolution imaging.
  • Employing functional imaging techniques including delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping.
  • Exploring the glycosaminoglycan chemical exchange-dependent saturation transfer (gagCEST) technique.

Main Results:

  • Excellent morphological imaging allows detection of subtle cartilage pathologies.
  • Functional imaging can identify early osteoarthritis by assessing cartilage composition.
  • Techniques like dGEMRIC, T2 mapping, and gagCEST aid in monitoring therapeutic interventions.

Conclusions:

  • Advanced MRI provides comprehensive morphological and functional assessment of cartilage.
  • Functional MRI techniques are vital for early diagnosis and monitoring of osteoarthritis.
  • Novel techniques like gagCEST offer promising avenues for biochemical cartilage assessment.