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Lung retinoid metabolism and signaling in chronic obstructive pulmonary disease

Salil K Das, Somdutta Sinha Roy, Shyamali Mukherjee

    Indian Journal of Biochemistry & Biophysics
    |April 1, 2015
    PubMed

    Insights

    All-trans retinoic acid (ATRA) plays a vital role in lung health. Disruptions in ATRA metabolism and trafficking are linked to lung diseases like COPD, especially after smoke exposure.

    Area of Science:

    • Pulmonary Medicine
    • Molecular Biology
    • Biochemistry

    Background:

    • All-trans retinoic acid (ATRA) is crucial for cellular function.
    • Disruptions in ATRA production, metabolism, and trafficking are implicated in various cancers.
    • Preliminary evidence suggests a link between these disruptions and smoke-induced lung disorders.

    Purpose of the Study:

    • To review the metabolism and trafficking of retinoids in the lung.
    • To explore the role of retinoid signaling in lung health and disease.
    • To highlight ATRA as a potential therapeutic strategy for lung conditions.

    Main Methods:

    • Literature review of retinoid metabolism and signaling pathways.
    • Analysis of the impact of interrupted retinoid trafficking on lung function.
    • Examination of ATRA's therapeutic potential in lung diseases.

    Main Results:

    • Specific sites are essential for ATRA production and action.
    • Interrupted retinoid metabolism and trafficking are associated with cancers and may contribute to lung disorders.
    • ATRA's role in protecting against lung functional abnormalities, including COPD, is supported.

    Conclusions:

    • Retinoid metabolism and trafficking are critical for maintaining lung health.
    • Dysregulation of these pathways, particularly due to smoke exposure, contributes to lung disease pathogenesis.
    • Targeting ATRA offers a promising therapeutic avenue for preventing and treating lung conditions like COPD.

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