Related Experiment Video
Updated: Apr 15, 2026
Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
Intraoperative fluorescein angiography-guided treatment in children with early Coats' disease
Martina Suzani1, Anthony T Moore2
1Moorfields Eye Hospital, London, United Kingdom; Department of Ophthalmology, San Gerardo Hospital, Monza, Italy.
Insights
Intraoperative fluorescein angiography (FA) guided treatment of early Coats
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Retinal Diseases
Background:
- Coats' disease is a rare, idiopathic retinal vascular anomaly.
- Early diagnosis and treatment are crucial for preserving vision in affected children.
- Intraoperative fluorescein angiography (FA) aids in precise identification of abnormal vessels.
Purpose of the Study:
- To evaluate the anatomical and visual outcomes of treating pediatric Coats' disease using intraoperative FA.
- To assess the efficacy of targeted treatment for telangiectatic vessels and nonperfused areas.
Main Methods:
- Retrospective case series of 25 children (2-15 years) with stage 2 Coats' disease.
- Treatment guided by intraoperative FA using a wide-angle retinal camera (RetCam II).
- Assessment of retinal anatomy, visual acuity (VA), and complications post-treatment.
Main Results:
- Twenty children with unilateral disease were analyzed with a median follow-up of 21 months.
- Fifteen eyes required one treatment, and five eyes needed a second treatment.
- No disease progression observed; 12 eyes achieved VA of 0.4 logMAR or better.
Conclusions:
- Intraoperative FA-guided treatment of stage 2 Coats' disease yields favorable anatomical results.
- Visual acuity is preserved in the majority of treated children.
- This approach effectively manages retinal telangiectasia and nonperfusion.
Purpose:
To review the anatomic and visual outcomes of a series of children diagnosed with Coats' disease and treated on the basis of intraoperative fluorescein angiography (FA) findings.
Design:
Retrospective case series.
Participants:
Twenty-five children 2 to 15 years of age diagnosed with early Coats' disease and treated after intraoperative FA.
Methods:
Retrospective review of patients who underwent treatment for stage 2 Coats' disease in a tertiary center in the United Kingdom between 2007 and 2012. The children underwent treatment to the telangiectatic vessels and associated areas of retinal nonperfusion identified on intraoperative FA performed with a wide-angle retinal camera (RetCam II).
Main Outcome Measures:
Anatomic and structural assessment of the retina after treatment, visual acuity (VA), and complications related to treatment.
Results:
Twenty children with Coats' disease who underwent intraoperative RetCam FA and retinal ablative treatment and who had more than 3 months of follow-up were identified from clinical records. All had unilateral disease. Six eyes were classified as stage 2a, and 14 eyes were classified as stage 2b. The median duration of follow-up was 21 months (mean, 26 months). Fifteen eyes needed 1 treatment to stabilize the disease, and 5 eyes needed a second treatment. None of the patients demonstrated progression of the disease to a more severe stage. Twelve eyes had a final VA of 0.4 logarithm of the minimum angle of resolution (logMAR) or better, 6 patients had VA between 0.4 and 1.0 logMAR, and 2 patients had VA worse than 1.0 logMAR.
Conclusions:
The treatment of retinal telangiectasia and areas of retinal nonperfusion identified by wide-angle intraoperative FA in children with stage 2 Coats' disease led to good anatomic outcome, with preservation of VA in most cases.
More Related Videos
10:24Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
Published on: February 19, 2014
04:08Fluorescence Angiography for Evaluation of Aneurysm Perfusion and Parent Artery Patency in Rat and Rabbit Aneurysm Models
Published on: July 24, 2019
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment