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CADASIL presenting as schizophreniform organic psychosis.

Cyrus S H Ho1, Adrian Mondry2

  • 1Department of Psychological Medicine, National University Hospital, National University Health System, Singapore.

General Hospital Psychiatry
|April 1, 2015
PubMed
Summary

This case report highlights a rare presentation of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with schizophreniform organic psychosis in an Asian female, emphasizing the need for early diagnosis.

Keywords:
AsianCADASILNeuropsychiatric symptomsSchizophreniform organic psychosis

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Area of Science:

  • Neurology
  • Psychiatry
  • Genetics

Background:

  • Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare genetic disorder affecting small blood vessels in the brain.
  • Neuropsychiatric symptoms are common in CADASIL, but frank psychosis is an infrequent manifestation.

Observation:

  • A case report detailing an Asian female patient with CADASIL who presented with schizophreniform organic psychosis.
  • The patient exhibited persistent distractibility and cognitive impairment following the resolution of psychotic symptoms.

Findings:

  • This case underscores the diverse and sometimes unusual neuropsychiatric presentations of CADASIL.
  • Psychotic symptoms, though rare, can be a significant feature of CADASIL, necessitating careful clinical recognition.

Implications:

  • Early recognition and diagnosis of CADASIL are crucial for timely management and intervention.
  • Understanding the spectrum of CADASIL manifestations, including psychosis, can improve patient care and outcomes.