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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
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Malignancy risk scoring of hydatidiform moles
Heru Pradjatmo1, Djaswadi Dasuki, Ery Kus Dwianingsih
1Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Gadjah Mada, Jogjakarta, Indonesia E-mail : pradjatmo@yahoo.com, herupradjatmo@gmail.com.
Asian Pacific Journal of Cancer Prevention : APJCP
|April 1, 2015
Summary
A new scoring system helps predict hydatidiform mole malignant transformation. A score of 31 or higher indicates high risk, enabling prompt prophylactic chemotherapy for early cancer prevention.
Area of Science:
- Gynecology
- Oncology
- Pathology
Background:
- Hydatidiform moles can undergo malignant transformation.
- Prophylactic chemotherapy reduces malignancy incidence in high-risk cases.
- Early identification of high-risk patients is crucial for timely intervention.
Purpose of the Study:
- To develop a predictive scoring system for hydatidiform mole malignant transformation.
- To identify key risk factors associated with malignant progression.
Main Methods:
- A case-control study comparing choriocarcinoma and benign hydatidiform mole patients.
- Multiple logistic regression analysis to determine risk factors.
- Calculation of odds ratios (OR) and risk indices.
- Receiver operating characteristic (ROC) curve analysis for optimal cut-off determination.
Main Results:
- Four significant risk factors identified: advanced maternal age (≥35 years), advanced gestational age (≥12 weeks), uterine size exceeding gestational age, and histopathological grade II-III.
- A scoring system was developed with scores ranging from 0 to 55.
- A cut-off score of ≥31 was determined to indicate high risk for malignancy.
Conclusions:
- The developed risk scoring system effectively predicts malignant transformation of hydatidiform moles.
- Patients with a score of ≥31 are considered high-risk and candidates for prompt prophylactic chemotherapy.
- This tool aids in early intervention and prevention of hydatidiform mole malignancy.
