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Related Experiment Video

Updated: Apr 15, 2026

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
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Meter-long multiblock copolymer microfibers via interfacial bioorthogonal polymerization.

Shuang Liu1, Han Zhang, Roddel A Remy

  • 1Department of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.

Advanced Materials (Deerfield Beach, Fla.)
|April 1, 2015
PubMed
Summary

Researchers created strong polymer fibers using bioorthogonal polymerization. Incorporating cell-adhesive peptides resulted in protein-mimetic fibers that guide cell attachment and elongation.

Keywords:
bioorthogonalfibersguidance cuesinterfacial polymerizationmultiblock copolymer

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Cell Biology

Background:

  • Multiblock copolymers offer tunable properties for advanced materials.
  • Bioorthogonal polymerization enables controlled synthesis in biological environments.
  • Cell-interactive materials are crucial for tissue engineering and regenerative medicine.

Purpose of the Study:

  • To synthesize high-molecular-weight multiblock copolymers into robust polymer fibers.
  • To develop protein-mimetic polymer fibers for guiding cell behavior.
  • To explore the utility of interfacial bioorthogonal polymerization for creating functional biomaterials.

Main Methods:

  • Interfacial bioorthogonal polymerization utilizing the cycloaddition of s-tetrazines with strained trans-cyclooctenes.
  • Incorporation of cell-adhesive peptides into the tetrazine monomer.
  • Characterization of synthesized polymer fibers and assessment of cell attachment and elongation.

Main Results:

  • Successful synthesis of high-molecular-weight multiblock copolymers as robust polymer fibers.
  • Demonstration of rapid cycloaddition kinetics for efficient polymerization.
  • Formation of protein-mimetic polymer fibers capable of providing guidance cues for cell attachment and elongation.

Conclusions:

  • Interfacial bioorthogonal polymerization is an effective method for synthesizing robust polymer fibers.
  • Protein-mimetic polymer fibers incorporating cell-adhesive peptides can direct cell behavior.
  • This approach offers a promising strategy for developing advanced biomaterials for cell-instructive applications.