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Regulation of EMMPRIN (CD147) on monocyte subsets in patients with symptomatic coronary artery disease

Henrik Sturhan1, Saskia N I v Ungern-Sternberg1, Harald Langer1

  • 1Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Germany.

Thrombosis Research
|April 1, 2015
PubMed
Abstract

Insights

Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) is highly expressed on classical monocytes. EMMPRIN levels are elevated in acute myocardial infarction patients, suggesting its potential as a biomarker for this cardiovascular disease.

Area of Science:

  • Immunology
  • Cardiovascular Medicine
  • Cell Biology

Background:

  • The specific roles of monocyte subsets in cardiovascular inflammation remain unclear.
  • Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) influences inflammation but its expression on monocytes is uncharacterized.

Purpose of the Study:

  • To investigate EMMPRIN expression on different monocyte subsets.
  • To assess EMMPRIN's potential as a biomarker in coronary artery disease (CAD) and acute myocardial infarction (AMI).

Main Methods:

  • Flow cytometry was used to analyze monocyte subsets (CD14(++)CD16(-), CD14(++)CD16(+), CD14(+)CD16(++)) in 80 stable CAD patients, 49 AMI patients, and 34 controls.
  • Surface expression of EMMPRIN was quantified and compared with CD36 and CD47.

Main Results:

  • EMMPRIN expression varied significantly across monocyte subsets, being highest on classical CD14(++)CD16(-) monocytes.
  • All monocyte subsets showed increased EMMPRIN expression in AMI patients compared to stable CAD patients.
  • CD47 and CD36 expression did not differ significantly between AMI and stable CAD patients.

Conclusions:

  • EMMPRIN can serve as a marker for classical monocytes.
  • Elevated EMMPRIN expression in acute myocardial infarction highlights its potential diagnostic value.
Keywords:
Acute coronary syndromeCD147Monocyte subsets

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